Directory Organisation

Organisation

Kreatech Biotechnology, The Netherlands

Area of Expertise

Medical and Dental

PGMs Used

Platinum

PGM Knowledge

Research and development of DNA and serologic diagnostic methods for the medical market.

Universal Linkage System (ULS^TM); A versatile non-enzymatic labeling technology

The proprietary ULS^TM technology provides the basis for Kreatech's broad range of labeling applications. ULS labeling is based on the stable coordinative binding properties of platinum to nucleic acids and proteins. The ULS molecule consists of a platinum complex, a detectable molecule and a leaving group which is displaced upon reaction with the target. This ULS molecule forms a coordinative bond, firmly coupling the ULS to the target. ULS labels DNA, and RNA by binding to the N7 position of guanine. In proteins, ULS binds to nitrogen and sulphur containing side chains of methionine, cysteine and histidine. ULS is available coupled to a variety of labels and haptens, including fluorochromes, biotin, dinitrophenol and horse radish peroxidase. The labeling reaction allows a wide range of conditions and produces a highly stable bond.