Table III

Antitumour Activity of Platinum Compound 6 in Mice with S180


Group	Dose, mg kg⁻¹	Treatment scheme	Number of mice	Tumour weight, g, x ± SD	T:C, %

Control	–	–	12	1.42 ± 0.25	–
Compound 6	30	i.p., d 1, 4	6	1.26 ± 0.34	83.4
	60		6	0.74 ± 0.51	53.1*
	90	i.p., d 1	6	0.96 ± 0.29	67.6*
Carboplatin	60	i.p., d 1, 4	8	0.62 ± 0.29	43.7*

Note: The compound was dissolved in arachis oil before administration; SD = standard deviation; d = day(s);

*P < 0.01 vs. control